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null Alexander Lawandi, MD, M.Sc., FRCPC

Junior Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

adaptive antimicrobial resistance bacteriology • life threatening infections • critical care • proteomics

Research Focus

My research is focused upon studying bacterial pathogens associated with life-threatening infections, particularly in the critically ill. We utilize proteomic approaches (both shotgun and targeted) to study how these pathogens adapt to antibacterial therapies being administered. Our goals are to characterize adaptations that may reduce therapeutic efficacy, and similarly, to understand how the pathogens modulate their virulence factors to cause disease. We further study post-translational modifications in bacteria to understand how they may be involved in the coordinated response to antibiotics with the aim of describing potential new drug targets.

Selected Publications

Click on Pubmed to see my current publications list

  • Strich JR, Mishuk A, Diao G, Lawandi A, Li W, Demirkale CY, Babiker A, Mancera A, Swihart BJ, Walker M, Yek C, Neupane M, De Jonge N, Warner S, Kadri SS; National Institutes of Health Antimicrobial Resistance Outcomes Research Initiative. Assessing Clinician Utilization of Next-Generation Antibiotics Against Resistant Gram-Negative Infections in U.S. Hospitals : A Retrospective Cohort Study. Ann Intern Med. 2024 Apr 19. doi: 10.7326/M23-2309. Epub ahead of print. PMID: 38639548.

  • Del Corpo O, Senécal J, Hsu JM, Lawandi A, Lee TC. Rapid phenotypic testing for detection of carbapenemase- or extended-spectrum ß-lactamase-producing Enterobacterales directly from blood cultures: a systematic review and meta-analysis. Clin Microbiol Infect. 2023 Dec;29(12):1516-1527. doi: 10.1016/j.cmi.2023.09.007. Epub 2023 Sep 16. PMID: 37722531.

  • Lawandi A, Oshiro M, Warner S, Diao G, Strich JR, Babiker A, Rhee C, Klompas M, Danner RL, Kadri SS. Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum: Real-World Utilization and Performance Characteristics, 65 U.S. Hospitals, 2008-2017. Crit Care Med. 2023 Nov 1;51(11):1527-1537. doi: 10.1097/CCM.0000000000005968. Epub 2023 Jul 3. PMID: 37395622.

  • Lawandi A, Leite GC, Cheng MP, Lefebvre B, Longtin J, Lee TC. Assessment of Piperacillin-Tazobactam-Meropenem Synergy against Serine Carbapenemase-Producing Enterobacterales Using Time-Kill Assays. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02317-20. doi: 10.1128/AAC.02317-20. PMID: 33468471.

  • Lawandi A, Leite G, Cheng MP, Lefebvre B, Longtin J, Lee TC. In vitro synergy of β-lactam combinations against KPC-producing Klebsiella pneumoniae strains. J Antimicrob Chemother. 2019 Dec 1;74(12):3515-3520. doi: 10.1093/jac/dkz389. PMID: 31730163.