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Ciriaco A. Piccirillo, PhD

Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Professor, Department of Microbiology and Immunology, Faculty of Medicine, McGill University

 

Keywords


immunology • T cell biology • autoimmune diseases • inflammatory diseases

Research Focus


My research focuses on the regulation of innate and adaptive immune responses mediated by Foxp3+ regulatory T (Treg) cells, a unique population of CD4+ T cells with potent immunosuppressive functions in humans and mice. Normal development and function of Foxp3+ Treg cells is essential for the protection from autoimmune diseases and developmental or functional defects in Treg cells in mice and humans unequivocally provokes many inflammatory and autoimmune diseases. Our research is responsible for many seminal studies over the past decade related to the function and mechanism of action of Treg cells in a variety of animal models, non-human primates and humans. My research program aims to determine whether Treg cell developmental, functional or homeostatic deficiencies trigger various inflammatory disorders, and in particular autoimmune diseases like type 1 diabetes (T1D). My laboratory exploits a spectrum of molecular and cellular approaches to study the development, dynamics and molecular basis of Treg cell function in health and disease.

Selected Publications


Click on Pubmed to see my current publications list

  • Bin Dhuban K et al. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. J Immunol. 2015 Apr 15;194(8):3687-96. PMID: 25762785.

  • Piccirillo CA et al. Translational control of immune responses: from transcripts to translatomes. Nat Immunol. 2014 Jun;15(6):503-11. PMID: 24840981.

  • Bjur E et al. Distinct translational control in CD4+ T cell subsets. PLoS Genet. 2013 May;9(5):e1003494. PMID: 23658533.

  • Kornete M et al. ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol. 2012 Feb 1;188(3):1064-74. PMID: 22227569.

  • d'Hennezel E et al. FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. N Engl J Med. 2009 Oct 22;361(17):1710-3. PMID: 19846862.