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Ernest Seidman, MD

Research Institute of the McGill University Health Centre

Regular Member
Endocrinology, Diabetes, Nutrition and Kidney Diseases
Infection and immunity


McGill University Health Centre (MUHC)

Director of Research, Division of Gastroenterology


McGill University

Departments of Medicine and Pediatrics


Research Interest


My research focuses on obtaining a better understanding of how immune system dysfunction results in "autoimmune" bowel disorders such as Crohn's disease, ulcerative colitis and celiac disease. My laboratory employs several complimentary research strategies, including cultured cell lines, experimental animal models, as well as bowel explants or isolated human cells from human gut biopsies or intestinal resections. In addition to studying the causes of these disorders, my research also focuses on non-invasive measures to detect and follow these disorders, as well as novel approaches to their treatment and prevention.

Research Foci


  • immune mediated bowel disorders
  • mucosal immunology
  • ulcerative colitis
  • crohn's disease
  • celiac disease
  • cell and molecular biology

Keywords


IBD, Crohn's disease, ulcerative colitis, celiac disease, translational research, genetics, colon cancer, autoimmune, intestinals

Selected Publications


Click on Pubmed to see my current publications list

  • S Dionne, MR Calderone, J White, B Memari, B Adelson, C Piccirillo, EG Seidman. Differential effect of vitamin D on NOD2-and TLR-induced cytokines in Crohn's disease. Mucosal Immunology 2014

  • Dionne S, Elimrani I, Roy MJ, Qureshi IA, Sarma DR, Levy E, Seidman EG Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer. Nutr Cancer 2012;64(8):1297-87.

  • Dassopoulos T, Dubinsky M, Bentsen J, Martin C, Galanko J, Seidman E, Sandler R, Hanauer S. A Randomized Trial of Individualized versus Weight-Based Dosing of Azathioprine in Crohn's Disease. Aliment Pharmacol Ther 2014; 39: 163-175.

  • Girardin M, Dionne S, Goyette P, Rioux J, Bitton A, Elimrani I, Charlebois P, Qureshi I, Levy E, Seidman EG. Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease. J Crohn's & Colitis 2012;6(2):189-97.

  • Silva MA, Menezes J, Dionne S, Levy E, Amre DK, Seidman EG. Herpes Simplex Virus-1 infection of colonic explants as a model of viral induced activation of Crohn's disease. J Crohn's & Colitis 2012 May;6(4) :454-63