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Erwin Schurr, PhD

RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Professor, Department of Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, McGill University

 

Keywords


tuberculosis • leprosy • complex traits • transcriptomics • systems biology

Research Focus


My research focuses on the identification and evaluation of host genetic factors in tuberculosis and leprosy. We are working with partner groups in endemic countries for those diseases and are applying modern concepts of genetics, genomics and sytems biology to our analyses.

Selected Publications


Click on Pubmed to see my current publications list

  • V.M. Fava, A. Cobat, N.V. Thuc, N.N. Ba, M. Orlova, J. Manry, A.C.P. Latini, M.M.A. Stefani, M. Mira, V.H. Thai, L. Abel, A. Alcaïs, E. Schurr Multiple genetic variants in regulatory regions for TNFSF8 are associated with pathological immune responses in leprosy, J Infect Dis, 211:968-977, 2015.

  • A. Cobat, L. Abel, A. Alcaïs, E. Schurr "A General Efficient and Flexible Approach for Genome-Wide Association Analyses of Imputed Genotypes in Family-Based Designs" Genet Epidemiol, 38:560-571, 2014 PMID: 25044438.

  • L. Abel, J. El-Baghdadi, A. Bousfiha, J.L. Casanova, E. Schurr "Human genetics of tuberculosis: A long and winding road" Phil Trans Roy Soc B, 369:2014 PMID: 24821915.

  • A. Cobat, E.G. Hoal, C.J. Gallant, L. Simkin, G.F. Black, K. Stanley, J.P. Jaïs, T.H. Yu, A. Boland-Auge, G. Grange, C. Delacourt, P. van Helden, J.L. Casanova, L. Abel, A. Alcaïs and E. Schurr "Identification of a major locus, TNF1, that controls BCG-triggered TNF production by leukocytes in an area hyperendemic for tuberculosis" Clin Infect Dis 57:963-970, 2013 PMID: 23800941.

  • M. Orlova, A. Cobat, N.T. Huong, N.N. Ba, N.V. Thuc, J Spencer, Y. Nédélec, L. Barreiro V.H. Thai, L. Abel, A. Alcais, E. Schurr "Gene set signature of reversal reaction type I in leprosy patients" PLoS Genetics, 9: e1003624;2013. PMID: 23874223.