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Giovanni (John) Di Battista, BSc, MSc, PhD

Senior Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Professor, Department of Medicine, Division of Experimental Medicine, Faculty of Medicine, McGill University

 

Keywords


signaling • genetics • proteomics • G protein-coupled receptors (GPCRs) • inflammation

Research Focus


My research focuses on G-protein coupled receptor signaling pathways regulating the inflammatory response.

Selected Publications


Click on Pubmed to see my current publications list

  • Casimiro Gerarduzzi, QingWen He, John Antoniou, and John A. Di Battista: Global phosphoproteomic analysis of signaling downstream of the ProstaglandinE2/G-protein coupled receptor in human synovial fibroblasts J Proteome Res. 2014 Nov 7;13(11):5262-80 PMID: 25223752.

  • Casimiro Gerarduzzi, QingWen He, John Antoniou, and John A. Di Battista. Prostaglandin E2-dependent blockade of fibroblast-to-myofibroblast transition is mediated through S1379 phosphorylation of rho-associated coiled coil-containing kinase-2: A phosphoproteomic analysis. J. Cell. Biol. 2014 Sep;115(9):1516-27.

  • Beibei Zhai, Huiqing Yang, Arturo Mancini, QingWen He, John Antoniou, and John A. Di Battista. Leukotriene B4 BLT receptor signalling regulates the level and stability of Cyclooxygenase-2 (Cox-2) mRNA through restricted activation of Ras/c-Raf/ERK/p42 auf1 pathway. J. Biol. Chem. 285(31): 23568-23580, 2010. PMID: 20489206.

  • Casimiro Gerarduzzi, QingWen He, John Antoniou, and John A. Di Battista: Prostaglandin E2-dependent phosphorylation of Ras inhibitor 1 at Ser 291 and 292 inhibits the Transforming Growth Factor-ß-induced Ras activation pathway in human synovial fibroblasts: Role in cell migration and differentiation." (FASEB J in press).

  • Arturo Mancini and John A. Di Battista. The Cardinal Role of the Phospholipase/Cyclooxygenase-2/ProstaglandinE synthase/Prostaglandin E2 (PCPP) Axis in Inflammostasis. Inflamm Res. 2011 Dec;60(12):1083-92 PMID: 21964881.