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Brian Ward, MD, DTM&H, MDCM

Research Institute of the McGill University Health Centre

Regular Member
Deputy Director of RI-MUHC (Fundamental Science)
Infection and immunity


McGill University Health Centre (MUHC)

Director, Division of Infectious Diseases
Associate Director , MUHC Adult Vaccine Study Centre
Medical Director , JD MacLean Tropical Diseases Centre
Director, National Reference Centre for Parasitology


McGill University

Professor, Faculty of Medicine, Departments of Experimental Medicine, Infection and Immunity and Parasitology


Research Interest


My research focuses on: the development and evaluation of novel virus-like particle vaccines (eg: influenza, measles) in both young and elderly subjects, international health issues with a particular focus on factors that influence HIV transmission, virus-nutritional interactions, and the development of new diagnostic tests for parasitic diseases. My laboratory sits at the junction between infectious diseases clinic and the basic science laboratory. Projects can start at either end of this spectrum and move from 'bed to the bench-top' or from 'bench-top to the bed'. Most of the basic work is carried out in Montreal with satellite facilities in Peru and Zimbabwe. Human vaccine studies are conducted at the MUHC Vaccine Study Centre in Pierrefonds, QC.

Research Foci


  • nanoparticle vaccines for negative-sense RNA viruses (influenza, measles, RSV, etc.)
  • impacts of nutrition, sanitation, the microbiome and genetics on HIV mother-to-child transmission
  • molecular mechanism of retinoids as novel antiviral agents
  • real-time PCR, nanoscale PCR, and proteomics as novel diagnostic tests for parasitic infections

Keywords


Vaccines, respiratory viruses, international health, parasitology, diagnostics

Selected Publications


  • Soye KS, Trottier C, DiLenardo T, Restori K, Miller WH Jr, Ward BJ. Retinoids inhibit mumps virus replication via RIG-I signalling and up-regulation of Type I interferon. Virology J 2013 (in press)

  • Qianqian Miao1, Santamaria C, Dana Bailey D, Fu M, Jacques Genest J, Ward BJ, Ndao M. Apolipoprotein A-I truncations in Chagas Disease are caused by cruzipain, the major cysteine protease of Trypanosoma cruzi. Am J Pathol 2013 (in press)

  • Yam KK, Gupta J, Scheifele DW, Scott Halperin S, Ward BJ Unusual pattern of IgG avidity in some young children following two doses of adjuvanted pandemic H1N1(2009) influenza vaccine. Clinical Vaccine Immunol 2013 Apr;20(4):459-67

  • Defay F, De Serres G, Skowronski DM, Boulianne N, Ouakki M, Landry M, Brousseau N, Ward BJ. Measles in Children Vaccinated With 2 Doses of MMR. Pediatrics. 2013 Oct 21.

  • Landry N, Ward BJ, Trepanier S, Montomoli E, Dargis M, Lapinin G, Vezina LP. Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza. Vaccine. 2011 Feb 24;29(10):1921-8.